The crash happened on US Rt 1 South near the ramp to Route 252 (Providence Road) around 8 a.m. on July 2, authorities say.
The driver of a transit van and two passengers have died, said the Delaware County District Attorney's Office. Their identities were not given.
The highway was closed between Exit: I-476 - Chester/Plymouth Meeting and Exit: PA 252 - Media/Newton Square. All lanes were reopened by 1:30 p.m.
The two-vehicle crash was initially reported to involve a trash truck on fire with people trapped, but dispatchers were unsure if that is what emergency crews discovered at the scene.
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